Polyubiquitin chains: polymeric protein signals.
By C. Pickart, D. Fushman. Current Opinion in Chemical Biology, 2004
1,096 citations recorded by the source corpus.
Subfields: Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/b9dff6c814e2ffa4f1d26e9c9512907e1cafabbc
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Citations in the corpus
- Mapping protein post-translational modifications with mass spectrometry (2007, methodology): “Because SUMOylated peptides often show inefficient cleavage owing to cross-linking and larger peptide size, strategies to improve coverage have used combinations of proteases as well as C-terminal SUMO mutants with shorter C-terminal tag”
- Molecular discrimination of structurally equivalent Lys 63‐linked and linear polyubiquitin chains (2009, background): “Hershko & Ciechanover, 1998 ), whereas most non-proteolytic functions of ubiquitin chains are currently associated with Lys 63-linked ubiquitin polymers”
- Type I interferon inhibits interleukin-1 production and inflammasome activation. (2011, background): “In polyubiquitin chains, ubiquitin monomers are usually linked via isopeptide bonds between an internal lysine of one monomer and the C-terminal glycine of the other monomer (Pickart and Fushman, 2004).”
- Reading protein modifications with interaction domains (2006, background): “In addition, ubiquitin contains seven Lys residues that can themselves be modified to form polyubiquitin chains, which can be built of homotypic (Lys48- or Lys63-) or heterotypic (mixed Lys29-, Lys48- and Lys63-) linkage”
- Ubiquitin-binding domains — from structures to functions (2009, background): “An attractive model that describes how the outcome of ubiquitylation is determined in cells proposed that the fate of ubiquitylated substrates depends on the type of ubiquitin linkage and the length of the ubiquitin chai”
- Ubiquitylation and cell signaling (2005, background): “…Organization | All Rights Reserved 0261-4189/05 www.embojournal.org &2005 European Molecular Biology Organization The EMBO Journal VOL 24 | NO 19 | 2005 EMBO THE JOURNAL 3353 Lys48, indicating that they likely have distinct targets and functions in the cell (Figure 1) (Pickart and Fushman, 2004).”