The Frailty Syndrome: Definition and Natural History

By Qian-Li Xue. Clinics in Geriatric Medicine, 2011

1,809 citations recorded by the source corpus.

This article reviews the current state of knowledge regarding the epidemiology of frailty by focusing on 6 specific areas: (1) clinical definitions of frailty, (2) evidence of frailty as a medical syndrome, (3) prevalence and incidence of frailty by age, gender, race, and ethnicity, (4) transitions between discrete frailty states, (5) natural history of manifestations of frailty criteria, and (6) behavior modifications as precursors to the development of clinical frailty.

Subfields: Economics and Econometrics, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/b9c12a98bc81cb741f3641b46b0dac2b68751b04

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Citations in the corpus

Effects of Different Exercise Interventions on Risk of Falls, Gait Ability, and Balance in Physically Frail Older Adults: A Systematic Review (2013, neutral): “In addition, other diseases, such as malnutrition, immobility, anemia, obesity, cancer, and cardiovascular disease, can accelerate the morbidity and mortality that are induced by the frailty syndrome.(10) Poor health, disability, and dependency do not have to be inevitable consequences of aging.”
The impact of frailty on intensive care unit outcomes: a systematic review and meta-analysis (2017, background): “For example, frail patients may be more difficult to wean from mechanical ventilation because of weakness, sarcopenia, and decreased oxygen uptake [9, 17, 18, 43].”
Association of frailty with survival: a systematic literature review. (2013, background): “Frailty occurs on a spectrum of severity, and defining the moment that frailty begins is difficult (Xue, 2011).”
Updating the Evidence for Physical Activity: Summative Reviews of the Epidemiological Evidence, Prevalence, and Interventions to Promote "Active Aging". (2016, background): “Frailty may be defined as a state of increased vulnerability resulting from age-related decline in reserve and function across multiple physiologic systems, attenuating the ability to cope with acute and chronic stressors, resulting in loss of homeostasis (Xue, 2011).”