Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: a population-based study

By Sean M. Bagshaw, Kevin B. Laupland, C. Doig, G. Mortis, G. Fick, Melissa Mucenski, Tomas Godinez-Luna, L. Svenson, T. Rosenal. Critical Care, 2005

615 citations recorded by the source corpus.

IntroductionSevere acute renal failure (sARF) is associated with considerable morbidity, mortality and use of healthcare resources; however, its precise epidemiology and long-term outcomes have not been well described in a non-specified population.MethodsPopulation-based surveillance was conducted among all adult residents of the Calgary Health Region (population 1 million) admitted to multidisciplinary and cardiovascular surgical intensive care units between May 1 1999 and April 30 2002. Clinical records were reviewed and outcome at 1 year was assessed.ResultssARF occurred in 240 patients (11.0 per 100,000 population/year). Rates were highest in males and older patients (≥65 years of age). Risk factors for development of sARF included previous heart disease, stroke, pulmonary disease, diabetes mellitus, cancer, connective tissue disease, chronic renal dysfunction, and alcoholism. The annual mortality rate was 7.3 per 100,000 population with rates highest in males and those ≥65 years. The 28-day, 90-day, and 1-year case-fatality rates were 51%, 60%, and 64%, respectively. Increased Charlson co-morbidity index, presence of liver disease, higher APACHE II score, septic shock, and need for continuous renal replacement therapy were independently associated with death at 1 year. Renal recovery occurred in 78% (68/87) of survivors at 1 year.ConclusionsARF is common and males, older patients, and those with underlying medical conditions are at greatest risk. Although the majority of patients with sARF will die, most survivors will become independent from renal replacement therapy within a year.

Subfields: Epidemiology, Nephrology

View Paper: https://www.semanticscholar.org/paper/b9b5d5504bb4ecefc9e10f877de490a596ecfcc0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Claudio Ronco
2. John A. Kellum
3. Sean M. Bagshaw
4. R. Bellomo

In Nephrology

1. John A. Kellum
2. Claudio Ronco
3. R. Bellomo
4. Sean M. Bagshaw
5. M. Ostermann
6. R. Chang

Citations in the corpus

• Chronic dialysis and death among survivors of acute kidney injury requiring dialysis. (2009, background): “Bagshaw et al observed a 1-year survival rate of 90% and a chronic dialysis rate of 22% among 97 Albertans discharged alive following dialysis for acute kidney injury.(13) While these studies clearly shed some light on the health outcomes of acute kidney injury survivors, most data were derived from”
• Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes. (2007, background): “Overall, there are limited data on renal recovery after septic AKI; however, higher rates of recovery to independence from RRT have been reported (9,43).”