The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria

By Xian-Zhi Li, P. Plésiat, H. Nikaido. Clinical Microbiology Reviews, 2015

1,281 citations recorded by the source corpus.

Subfields: Molecular Medicine, Pharmacology, Pollution

View Paper: https://www.semanticscholar.org/paper/b9b4c6cf405d9706d8b541c5817402cabee282df

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Medicine

1. Bernd H. A. Rehm
2. S. Ghods
3. David L. Paterson
4. M. F. Moradali

In Pharmacology

1. Michael Kuhn
2. Peer Bork
3. David L. Paterson
4. Patrick Aloy
5. Miquel Duran-Frigola

In Pollution

1. Bernd H. A. Rehm

Citations in the corpus

• Biofilms as Promoters of Bacterial Antibiotic Resistance and Tolerance (2020, background): “MarA, BrlR, SoxS, Rob, and AcrR are very well-known regulators of pump production in pathogenic bacteria [155].”
• Extensive impact of non-antibiotic drugs on human gut bacteria (2018, positive): “To test this hypothesis, we selected TolC, known to efflux several antibiotics in E. coli and other bacteria 27, as a prominent representative of a common resistance mechanism against antibiotics.”
• Epidemiology and Treatment of Multidrug-Resistant and Extensively Drug-Resistant Pseudomonas aeruginosa Infections (2019, background): “Constitutive expression of the MexAB-OprM efflux pump plays a major role in lower basal levels of susceptibility to the vast majority of -lactams (except for imipenem) and fluoroquinolones, whereas inducible production of MexXY has a major effect on the intrinsic low-level resistance to aminoglycosi”
• Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics (2022, background): “superfamily, major facilitator superfamily (MFS), and multidrug, toxic compound extrusion (MATE) family, resistance-nodulationdivision (RND) family, and small multidrug resistance (SMR) family.(239) Among all efflux pumps, the RND efflux pump family has the strongest correlation with antibiotic resi”
• Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence (2017, background): “Accordingly, we will review the central regulatory role of quorum sensing and signaling systems by nucleotide-based second messengers resulting in different lifestyles of P. aeruginosa.”
• Antimicrobial Resistance in ESKAPE Pathogens (2020, background): “baumannii is associated with imipenem resistance (234).”