The inflammatory responses to silk films in vitro and in vivo.

By L. Meinel, S. Hofmann, V. Karageorgiou, C. Kirker-Head, J. McCool, G. Gronowicz, L. Zichner, Robert Langer, G. Vunjak‐Novakovic, David Kaplan. Biomaterials, 2005

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Stem cell-based tissue engineering with silk biomaterials. (2006, background): “The useful combination of high strength, porosity, processability, good biocompatibility and ability to support cell adhesion, proliferation and differentiation as reviewed above suggests 3D porous silk fibroin scaffolds as candidates for stem cell- and chondrocyte-based cartilage tissue engineering”
Materials fabrication from Bombyx mori silk fibroin (2011, positive): “The inflammatory response to silk films was evaluated in vitro with hMSCs or by seeding rat MSCs on the films and implanting them in vivo”
Electrospinning: a fascinating fiber fabrication technique. (2010, background): “…it has several distinctive biological properties including good biocompatibility, biodegradability, and minimal inflammatory reaction and excellent mechanical properties (Gosline et al., 1986; Altman et al., 2003; Park et al., 2004; Meinel et al., 2005; Dal Pra et al., 2005; Horan et al., 2005).”
Neural tissue engineering options for peripheral nerve regeneration. (2014, background): “The inflammatory potential needs to be reflected in the specifications for biomaterials suitable for neural scaffolds [69], and the implanted neural scaffold biomaterial must be elaborately monitored for this inflammatory potential.”