Antibody neutralization and escape by HIV-1

By Xiping Wei, J. Decker, Shuyi Wang, H. Hui, J. Kappes, Xiaoyun Wu, J. Salazar-Gonzalez, M. Salazar, J. Kilby, M. Saag and 5 more. Nature, 2003

2,588 citations recorded by the source corpus.

Subfields: Immunology, Virology

View Paper: https://www.semanticscholar.org/paper/b91a3c816cb97688d62d23797ed4cc29232f44cc

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Citations in the corpus

Structural definition of a conserved neutralization epitope on HIV-1 gp120 (2007, neutral): “Genetic, immunological and structural studies of the HIV-1 envelope glycoproteins have revealed extraordinary diversity, manifest in a variety of immunodominant loops, as well as multiple overlapping mechanisms of humoral evasion, including self-masquerading glycan and conformational masking 8–11 .”
Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia (2008, background): “Autologous neutralizing antibodies target envelope variable loops (46, 49, 50, 60) that can arise long after any window of opportunity to extinguish HIV-1 has passed.”
Evaluating Neutralizing Antibodies Against HIV, SIV, and SHIV in Luciferase Reporter Gene Assays (2004, neutral): “Another useful cell line, TZM-bl (also called JC53BL-13), is a HeLa cell clone that was engineered to express CD4, CXCR4 and CCR5 and to possess tat-responsive reporter genes for Luc and β-galactosidase (Platt et al., 1998; Wei et al., 2003).”
Comprehensive Cross-Clade Neutralization Analysis of a Panel of Anti-Human Immunodeficiency Virus Type 1 Monoclonal Antibodies (2004, background): “This is probably because the V3 loop is frequently sequestered in neutralization-resistant isolates (13, 146).”
Distribution and three-dimensional structure of AIDS virus envelope spikes (2006, background): “The MPER is the most highly conserved region in the transmembrane glycoprotein(27) and has been proposed to serve as (1) a flexible extender(8), (2) a contributor to trimer formation and stability(31,32), and (3) an agent for membrane destabilization that fosters membrane fusion(27).”
Tiered Categorization of a Diverse Panel of HIV-1 Env Pseudoviruses for Assessment of Neutralizing Antibodies (2009, background): “However, the ability to design immunogens that can elicit such broadly reactive neutralizing antibodies (NAbs) has proven to be a formidable obstacle, due in part to the extensive genetic diversity of HIV-1 and the complex escape mechanisms employed by the envelope gp120 and gp41 glycoproteins that ”
Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2004 (2006, background): “However, during primary HIV infection both the antibody and the cell-mediated immune responses exert a selection pressure on the infecting virus, resulting in the rapid generation of escape mutants resistant to antibody neutralization and/or cytotoxic T-cell-(CTL) mediated killing [23,24].”
Learning the language of viral evolution and escape (2020, positive): “…learns escape patterns that can be linked to mutations, rather than post-translational changes like glycosylation that contribute to HIV escape (Wei et al., 2003), which may explain the lack of statistically significant escape potential assigned to Env glycosylation sites ( Figure 4C and Table…”
Epitope-Independent Purification of Native-Like Envelope Trimers from Diverse HIV-1 Isolates (2016, background): “HIC-purified SOSIP trimers also showed low binding ( 40 nm · s) over short periods to F105, b12, and 17b—antibodies with epitopes that are difficult to access and bind in the NL trimeric conformation (10) of most Env isolates studied to date.”
Global trends in molecular epidemiology of HIV-1 during 2000–2007 (2011, background): “HIV infection in humans induces humoral and cellular immune responses which control primary viraemia without completely eliminating infection due to the rapid selection of immune escape mutants [15,16].”