From haematopoietic stem cells to complex differentiation landscapes
By E. Laurenti, Berthold Göttgens. Nature, 2018
717 citations recorded by the source corpus.
The development of mature blood cells from haematopoietic stem cells has long served as a model for stem-cell research, with the haematopoietic differentiation tree being widely used as a model for the maintenance of hierarchically organized tissues. Recent results and new technologies have challenged the demarcations between stem and progenitor cell populations, the timing of cell-fate choices and the contribution of stem and multipotent progenitor cells to the maintenance of steady-state blood production. These evolving views of haematopoiesis have broad implications for our understanding of the functions of adult stem cells, as well as the development of new therapies for malignant and non-malignant haematopoietic diseases.
Subfields: Hematology, Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/b906b45b53cabc50ecc6c526b93c1858e03e2f0b
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- Jason D. Buenrostro
- W.J. Greenleaf
- Beijing Wu
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- Howard Y. Chang
- R. Majeti
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Citations in the corpus
- Integrated single-cell analysis maps the continuous regulatory landscape of human hematopoietic differentiation (2018, background): “…next sought to measure chromatin accessibility differences within stringently defined HSC and LMPP progenitors, populations previously described as primed toward different lineage fates (Busch et al., 2015; Karamitros et al., 2018; Laurenti and Göttgens, 2018; Naik et al., 2013; Pei et al., 2017).”