CT Imaging of the 2019 Novel Coronavirus (2019-nCoV) Pneumonia

By J. Lei, Junfeng Li, Xun Li, X. Qi. Radiology, 2020

677 citations recorded by the source corpus.

References 1. Zhu N, Zhang D, Wang W, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med 2020 Jan 24. doi: 10.1056/ NEJMoa2001017. [Epub ahead of print] 2. Munster VJ, Koopmans M, van Doremalen N, van Riel D, de Wit E. A Novel Coronavirus Emerging in China Key Questions for Impact Assessment. N Engl J Med 2020 Jan 24. doi: 10.1056/NEJMp2000929. [Epub ahead of print] A 33-year-old woman presented to the hospital with a 5-day history of fever and cough of unknown cause. She indicated that she worked in Wuhan, China (the center of novel coronavirus outbreak) but had traveled to Lanzhou, China, 6 days before presentation to the hospital. At admission, her body temperature was elevated to 39.0°C (102.2°F) and coarse breath sounds of both lungs were heard at auscultation. Laboratory studies showed leucopenia (white blood cell count: 2.91 3 109/L). The white blood cell differential count showed 70.0% neutrophils and 0.1% eosinophils. There were elevated blood levels for C-reactive protein (16.16 mg/L; normal range, 0–10 mg/L), erythrocyte sedimentation rate (29 mm/h; normal range, ,20 mm/h), and D-dimer (580 ng/mL; normal range, 500 ng/mL). Unenhanced chest CT showed multiple peripheral ground-glass opacities in both lungs (Figure, A) that did not spare the subpleural regions. Real-time fluorescence polymerase chain reaction of the patient’s sputum was positive for the 2019 novel coronavirus (2019-nCoV) nucleic acid. Unenhanced CT images in a 33-year-old woman. A, Image shows multiple ground-glass opacities in bilateral lungs. Ground-glass opacities are seen in the posterior segment of right upper lobe and apical posterior segment of left superior lobe. B, Image obtained 3 days after follow-up shows progressive ground-glass opacities in the posterior segment of right upper lobe and apical posterior segment of left superior lobe. The bilateralism of the peripheral lung opacities, without subpleural sparing, are common CT findings of the 2019 novel coronavirus pneumonia.

Subfields: Infectious Diseases, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/b90161898ff5ef4236f1c19a5c88138e1c80c5ea

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In Infectious Diseases

In Radiology, Nuclear Medicine and Imaging

Citations in the corpus

Imaging Profile of the COVID-19 Infection: Radiologic Findings and Literature Review (2020, neutral): “In China, the disease center, imaging has been at the forefront of investigation for patients with suspected or confirmed COVID-19 infection.”
Coronavirus Disease 2019 (COVID-19): Role of Chest CT in Diagnosis and Management. (2020, background): “In addition, the detailed CT features of COVID-19 have been reported in only a small number of articles in the literature [4, 7, 8].”
Coronavirus Disease 2019 (COVID-19): A Systematic Review of Imaging Findings in 919 Patients. (2020, neutral): “Lei [14] Yes Yes NA NA NA Yes CD NA Yes Fair Fair”
Chest CT Severity Score: An Imaging Tool for Assessing Severe COVID-19 (2020, background): “At imaging, CT manifestations resemble those seen in viral pneumonias (9), with multifocal ground-glass opacities and consolidation in a peripheral distribution being the most common findings (10,11).”
SARS-CoV-2 infection: The role of cytokines in COVID-19 disease (2020, neutral): “In some cases, treatment with inhalers and interferon not only had no positive effects but also worsened the clinical symptoms, with the progression of pulmonary opacities [17,20].”
Coronavirus Disease 2019 (COVID-19): A Perspective from China (2020, background): “CT Imaging Findings To date, only five case series studies (16,40-43) and some case reports (44-54) have investigated the chest CT imaging features of COVID-19 pneumonia.”
Diagnosis of the Coronavirus disease (COVID-19): rRT-PCR or CT? (2020, result): “Pleural effusion and lymphadenopathy were rarely observed, consistent with previous studies([20-22]).”
Emerging 2019 Novel Coronavirus (2019-nCoV) Pneumonia (2020, result): “9) Two lobes 8 (16) 64 (5) Three lobes 6 (12) 54 (4) Four lobes 12 (24) 276 (21) Five lobes 20 (39) 918 (69) Involved lung zones Upper lobes 43 (84) 485 (37) Middle lobe 30 (59) 136 (10) Lower lobes 46 (90) 703 (53) Predominant distribution Anterior 9 (18) 145 (11) Posterior 41 (80) 1179 (89) Periph”
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues (2020, neutral): “Overall, our data provide motivation to better understand the trade-offs of antiviral and/or IFN therapy in humans infected with SARS-CoV-2 in order to balance host restriction, tissue tolerance, and viral enhancement mechanisms (Davidson et al., 2015; Fung and Liu, 2019; Imai et al., 2005; Iwasaki ”
The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak (2020, background): “The patient's sputum showed positive real-time polymerase chain reaction results that confirmed COVID-19 infection [14].”
Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in Turkey (2021, background): “Male 42 193 59 64 40 [30-50] 77 [71-82] 97 [96-98] 6 [5-7] 41 [36-47]”
COVID_MTNet: COVID-19 Detection with Multi-Task Deep Learning Approaches (2020, background): “Recent reports also support this phenomenon [2,3].”
Deep Learning-based Detection for COVID-19 from Chest CT using Weak Label (2020, background): “In a word, chest CT is a key component of the diagnostic procedure for suspected patients and its CT manifestations have been emphasized in several recent reports [1, 9, 10, 11, 12].”