Toxin-antitoxin systems in bacterial growth arrest and persistence.

By R. Page, W. Peti. Nature Chemical Biology, 2016

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Mechanisms of bacterial persistence during stress and antibiotic exposure (2016, background): “Bacterial toxin-antitoxin (TA) modules are genetic elements composed of a toxin protein that inhibits bacterial growth by interfering with essential cellular processes and an antitoxin that prevents or impairs the functionality of the toxin until this inhibition is abrogated in response to cellular ”
Antibiotic resistance in Staphylococcus aureus. Current status and future prospects (2017, background): “protein kinase that acts on glutamyl aminoacyl tRNA synthetase are expressed constitutively along with a specific antitoxin that normally inhibits activity of the toxins (Page and Peti 2016).”
Antibiotic resistance and persistence—Implications for human health and treatment perspectives (2020, positive): “Today, numerous publications support the model of TA loci cumulatively regulating antibiotic persistence in E. coli (Vazquez-Laslop et al , 2006; Dorr et al , 2010; Page & Peti, 2016).”