Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

By M. Plattén, E. Nollen, Ute F. Röhrig, Francesca Fallarino, C. Opitz. Nature reviews. Drug discovery, 2019

1,331 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Psychiatry and Mental health, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/b8d3be8b53d887739c0cbd104b3b46a49fdc50e1

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Citations in the corpus

• Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects (2020, background): “In TME, the high expression of IDO can lead to the decrease of tryptophan and the accumulation of kynurenine, inhibit the activation of T cells and induce the production of Tregs [60, 61].”