Inter-residue, inter-protein and inter-family coevolution: bridging the scales
By H. Szurmant, Martin Weigt. 2017
73 citations recorded by the source corpus.
Interacting proteins coevolve at multiple but interconnected scales, from the residue-residue over the protein-protein up to the family-family level. The recent accumulation of enormous amounts of sequence data allows for the development of novel, data-driven computational approaches. Notably, these approaches can bridge scales within a single statistical framework. While being currently applied mostly to isolated problems on single scales, their immense potential for an evolutionary informed, structural systems biology is steadily emerging.
Subfields: Cell Biology, Molecular Biology
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In Molecular Biology
- Matteo Figliuzzi
- Pierre Barrat-Charlaix
- Martin Weigt
- Anne-Florence Bitbol
- Sergey Ovchinnikov
- Yang Zhang
- José N. Onuchic
- H. Szurmant
Citations in the corpus
- How Pairwise Coevolutionary Models Capture the Collective Residue Variability in Proteins? (2018, background): “Furthermore, studies about protein mutational effects [26] and the prediction of protein-protein interactions [27] have underlined the importance of pairwise couplings.”