Genetic rescue of small inbred populations: meta-analysis reveals large and consistent benefits of gene flow.

By R. Frankham. Molecular Ecology, 2015

780 citations recorded by the source corpus.

Subfields: Genetics

View Paper: https://www.semanticscholar.org/paper/b8355260d684f8bd70188cc84b12098eac3997b1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. R. Frankham
2. A. Hoffmann
3. B. Mable
4. R. Lacy
5. P. Hedrick
6. J. Ballou
7. C. Fenster
8. K. Ralls

Citations in the corpus

• Conservation of adaptive potential and functional diversity: integrating old and new approaches (2018, background): “Frankham (2015) performed a meta-analysis demonstrating the success of genetic rescue across generations for the limited number of examples available but demonstrated consistent benefits of outcrossing for inbred populations in both stressful and benign environments.”
• Mix and match: regional admixture provenancing strikes a balance among different seed-sourcing strategies for ecological restoration (2018, neutral): “2012; Frankham 2015).”
• Hybridization and extinction (2016, background): “However, this dataset is restricted to cases screened for ‘low risk’ of outbreeding depression: wild, intraspecific, adapted to similar environments, having experienced gene flow within 500 years, and with no fixed chromosomal differences (Frankham et al. 2011; Frankham 2015).”
• Genetics and extinction and the example of Isle Royale wolves (2019, background): “In addition, meta-analysis has suggested that genetic rescue provided benefits in a very high proportion of the cases examined (Frankham, 2015) and that these benefits persist for several generations (Frankham, 2016).”
• Hybridization as a conservation management tool (2019, background): “However, the risk of outbreeding depression has likely been overstated (Frankham, 2015; Hoffmann et al., 2015) and empirical evidence of inbreeding depression is vastly greater than that of outbreeding depression (Edmands, 2007).”
• Call for a Paradigm Shift in the Genetic Management of Fragmented Populations (2018, background): “The predicted benefits of genetic rescue are large: a recent meta-analysis showed that the median fitness increase in wild populations that naturally outbreed was 162.5% in stressful or wild environments (Frankham 2015).”