Social amnesia in mice lacking the oxytocin gene

By J. N. Ferguson, L. Young, E. Hearn, M. Matzuk, Thomas R. Insel, J. T. Winslow. Nature Genetics, 2000

1,088 citations recorded by the source corpus.

Subfields: Genetics, Sensory Systems, Social Psychology

View Paper: https://www.semanticscholar.org/paper/b79c590e1ce2cea8cea0d1e75d6974fef470c61a

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Citations in the corpus

Oxytocin and the neural mechanisms regulating social cognition and affiliative behavior. (2009, background): “This is not due to deficits in general learning and memory or olfaction since they do habituate to non-social odors [78].”
Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress. (2004, background): “The oxytocin knockout mouse exhibits a specific deficit in social recognition in the context of intact general cognitive abilities and olfactory processing (191).”
Oxytocin: the Great Facilitator of Life (2009, positive): “Interestingly, mice lacking the Oxt gene throughout the brain and body do not show deficits on the MWM or Y-maze, indicating that Oxt is not necessary for spatial memory (Ferguson et al., 2000).”
Involvement of estrogen receptor α, β and oxytocin in social discrimination: a detailed behavioral analysis with knockout female mice (2006, background): “These mice performed normally in tests for olfaction (Ferguson et al. 2000) and displayed normal olfactory-based avoidance of a stressed conspecific or predators (Kavaliers et al. 2004, 2005a, b; M. Kavaliers, A. Ågmo, E. Choleris, J.-Å.”
The neurobiology of attachment (2001, background): “Oxytocin knockout mice, capable of full maternal behaviour, show a profound social amnesia without other evident cognitive deficit”
Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes (2009, methodology): “12–14-week-old male mice were single-housed for a week before habituating to a clean novel cage for 1 h before testing, as described previousl”
The neurobiology of pair bonding (2004, positive): “Oxytocin knockout mice fail to recognize individuals to which they have been previously expose”
Oxytocin promotes human ethnocentrism (2011, background): “For example, studies on animal cognition show that male rodents engineered to lack forebrain oxytocin receptors recognized but no longer discriminated between familiar (ingroup) and novel (out-group) stimulus females (20, 21).”
A neurobehavioral model of affiliative bonding: implications for conceptualizing a human trait of affiliation. (2005, background): “Also, OT knockout mice are deficient in forming social recognition memories (Ferguson et al. 2000; Nishimori et al. 1996; Winslow & Insel 2002), an effect that may be a result of the lack of OT, and hence, of OT receptor activation, in the medial nucleus of the amygdala and in the BNST, where…”
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice (2004, background): “…both habituation of olfactory responses directed toward an unfamiliar conspecific, and dishabituation, with a reinstatement of social sniffing, when a novel stimulus animal is presented (Bluthe et al. 1993; Dluzen & Kreutzberg 1993; Ferguson et al. 2000; Kogan et al. 2000; Winslow & Camacho 1995).”
The neural correlates of maternal and romantic love (2004, background): “The neurohormones oxytocin and vasopressin have been shown to be crucially involved in both maternal attachment and adult pair-bonding in animals (Insel and Young, 2001; Kendrick, 2000; Pedersen, 1997), and may even play a more general role in mediating social memory and learning (Ferguson et al., 2”
The Neurobiology of Parental Behavior (2003, background): “Note that OT-KO mice lose social memory but show no other cognitive deficits (Ferguson et al., 2000), and rat pups treated with an oxytocin antagonist fail to learn odors associated with mother but have no deficit learning odors associated with nonsocial cues (Nelson & Panksepp, 1996).”