Establishment and Dysfunction of the Blood-Brain Barrier
By Zhen Zhao, Amy R. Nelson, C. Betsholtz, Berislav Zlokovic. Cell, 2015
1,493 citations recorded by the source corpus.
Structural and functional brain connectivity, synaptic activity and information processing require highly coordinated signal transduction between different cell types within the neurovascular unit and intact blood-brain barrier (BBB) functions. Here, we examine the mechanisms regulating the formation and maintenance of the BBB and functions of BBB-associated cell types. Furthermore, we discuss the growing evidence associating BBB breakdown with the pathogenesis of inherited monogenic neurological disorders and complex multifactorial diseases including Alzheimer’s disease.
Subfields: Molecular Biology, Neurology
View Paper: https://www.semanticscholar.org/paper/b78ab973592057a2b7b2584ebce15312a195f4a1
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- Tiantian Guo
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Citations in the corpus
- The blood–brain barrier: Structure, regulation and drug delivery (2023, background): “70,71 Moreover, for invertebrates that lack a vascularized circulatory system, astrocytes are the main components of the barrier separating humoral fl uids from the CNS. 72 Pericytes .”
- Vascular dysfunction – the disregarded partner of Alzheimer’s disease (2019, neutral): “[73] Zhao Z, Nelson AR, Betsholtz C, Zlokovic BV.”
- White matter changes in Alzheimer’s disease: a focus on myelin and oligodendrocytes (2018, neutral): “Vascular and blood brain barrier (BBB) impairments, small hemorrhagic lesions and buildup of iron have been reported in the brains of AD patients even in the preclinical stages of the disease [86].”
- Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020, background): “The BBB prevents neurotoxic plasma components, pathogens, and blood cells from entering the brain, and regulates the molecular transport of components into and out of the CNS to homeostatically regulate the neuronal extracellular environment [623, 624].”
- Impact of Hypertension on Cognitive Function (2016, neutral): “mal influx and efflux transporters regulating the exchange of molecules between blood and brain and vice versa.(70,71)”