Sensitive optical biosensors for unlabeled targets: a review.

By Xudong Fan, Ian M. White, S. Shopova, Hongying Zhu, J. D. Suter, Yuze Sun. Analytica Chimica Acta, 2008

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Fiber-Optic Surface Plasmon Resonance Sensors and Biochemical Applications: A Review (2020, background): “SPR sensors play a vital role in label-free biosensors because of their high sensitivity to the changes in refractive index (RI) and biomolecular behavior occurring in the electromagnetic field near a sensing surface [3]–[5].”
Emerging applications of label-free optical biosensors (2017, methodology): “For these purposes, the use of instruments based on surface plasmon resonance (SPR) is widely consolidated, although several other techniques have been reported to enable high detection performance [11, 12].”
Fluid-Filled Solid-Core Photonic Bandgap Fibers (2009, background): “label-free detection of biomolecules are based on measuring slight changes in refractive index resulting from bonding events between molecules attached to a surface [81].”
Review of plasmonic fiber optic biochemical sensors: improving the limit of detection (2015, background): “Using such resonances in sensing has been the object of much research, dating back over 20 years, as reviewed elsewhere [4] [5] [6] [7] [8] .”