Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes.

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Human disease classification in the postgenomic era: A complex systems approach to human pathobiology (2007, background): “There are many reasons for these different clinical phenotypes, including the presence of disease-modifying genes (Sebastiani et al, 2005) and environmental influences (ambient oxygen concentration, infection, dehydration), which can interact to yield different phenotypes ( Kato et al, 2007 ).”