Vitamin D Deficiency and Risk of Cardiovascular Disease

By Thomas J. Wang, Michael J. Pencina, S. Booth, P. Jacques, E. Ingelsson, Katherine J. Lanier, Emelia J. Benjamin, Ralph B. D’Agostino, M. Wolf, Ramachandran S. Vasan. Circulation, 2008

2,648 citations recorded by the source corpus.

Subfields: Orthopedics and Sports Medicine, Pathology and Forensic Medicine, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/b71220c37399cc2b843d6d4e24ea9c081feb1460

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Citations in the corpus

The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. (2012, neutral): “This includes the Framingham Osteoporosis Study for all CV events (201).”
Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis (2010, result): “The findings of that study might differ from ours for several reasons. The Women’s Health Initiative used low dose vitamin D supplements, and vitamin D deficiency has been associated with increased risk of cardiovascular disease”
Systematic Review: Vitamin D and Cardiometabolic Outcomes (2010, background): “The Framingham Offspring Study (36) found an association between lower 25(OH)D concentration and increased risk for overall cardiovascular events; however, this association seemed to be nonlinear (somewhat U-shaped) and subgroup analyses (not shown here) indicated that the association was statistica”
Vitamin D for Health: A Global Perspective (2013, neutral): “48) but not in those without hypertension.(152) Observational studies indicated that a serum 25(OH)D level less than 30 ng/mL was strongly associated with hypertension and metabolic syndrome.”
Guidelines for preventing and treating vitamin D deficiency and insufficiency revisited. (2012, background): “However, the association of vitamin D deficiency with a 50% increased risk of having a myocardial infarction (44), more than 100% increased risk of dying of the event (45), and an increased risk for colorectal cancer (43, 47) was dismissed as not being supported by RCTs.”
Adiposity, Cardiometabolic Risk, and Vitamin D Status: The Framingham Heart Study (2009, neutral): “From the (1) Framingham Heart Study, Framingham, MA; (2) Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA; (3) Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA; (4) Clinical Investigat”
Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. (2011, background): “36) for incident cardiovascular events compared with those with levels above 15 ng/ml (137).”
Baseline Serum 25-Hydroxy Vitamin D Is Predictive of Future Glycemic Status and Insulin Resistance (2008, background): “Diabetes 57:2619–2625, 2008 Though the most well-known role of vitamin D is the regulation of calcium absorption and bone metabolism, it is becoming clear that this hormone has pleiotropic effects with possible roles in the pathogenesis of cancer (1), cardiovascular disease (2), multiple sclerosis (”
Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography. (2008, background): “4 yr, in which 120 nonfatal and fatal cardiovascular events occurred, low vitamin D levels were independently associated with an increased risk of cardiovascular events (41).”
Vitamin D and cardiovascular disease. (2014, background): “In the Framingham Offspring Study, there was a nonlinear relationship between baseline vitamin D status and the adjusted hazard ratio for incident cardiovascular events.(136) Carotid intima/media thickness and cardiac calcification scores were also found to have a bimodal distribution across 25(OH)D”
Prevalence and correlates of vitamin D deficiency in US adults. (2011, background): “Thus, Vitamin D deficiency might contribute to development and progression of hypertension and cardiovascular disease [11-14].”