A Fine-Scale Map of Recombination Rates and Hotspots Across the Human Genome

By S. Myers, L. Bottolo, C. Freeman, G. McVean, Peter Donnelly. Science, 2005

1,169 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b6f1ecc775b58c46f694016105a1a78fd8a39541

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Citations in the corpus

A high resolution HLA and SNP haplotype map for disease association studies in the extended human MHC (2006, methodology): “Recombination rates and the location of recombination hotspots with strong statistical support were estimated from patterns of genetic variation using previously described method”
Insights into hominid evolution from the gorilla genome sequence (2012, background): “Thisisprimarily sensitivetoancestralcrossovereventsbeforehuman–chimpanzeespe-ciation,yetdespitetheexpectationofrapidturnoverinrecombination hotspots 19 , averaged over 1-Mbp windows there is a good correlation with estimates from present-day crossovers in humans ( R 5 0.49; P , 10 2 13 ;…”
Detection of sharing by descent, long-range phasing and haplotype imputation (2008, background): “Studying fine-scale recombination There is much interest in recombination hot spots and their evolutio”
Widespread Genomic Signatures of Natural Selection in Hominid Evolution (2009, background): “Plots show the percentage of the genome that is within a given distance of a conserved segment (solid curve) or protein coding sequence (broken curve). (A) Physical distances. (B) Genetic distances according to a fine-scale recombination map”
PLINK: a tool set for whole-genome association and population-based linkage analyses. (2007, methodology): “With dense SNP maps, the method is not particularly P(Z) sensitive to the precise genetic map used: in practice, a basic approximation appears to work well, 1 cM p 1 Mb although one could also use the fine-scale recombination map.(36) For each pair of individuals, we estimate the least number of mei”
Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions (2009, background): “direction to the nearest recombination hotspot [ 51 ].”
A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies (2009, methodology): “As with IMPUTE v1, we use an estimated fine-scale recombination map [17] for SNP-to-SNP transition probabilities and a result from population genetics theory [6] for emission probabilities, which model historical mutation.”
Computational and experimental identification of novel human imprinted genes. (2007, methodology): “We downloaded coordinates of recombination hotspots (Myers et al. 2005) from the International HapMap Project Web site (http://www.”