Fracture healing under healthy and inflammatory conditions

By Lutz Claes, S. Recknagel, A. Ignatius. Nature Reviews Rheumatology, 2012

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Mesenchymal stem cell-macrophage crosstalk and bone healing (2018, background): “required for optimal fracture healing [7, 8, 11].”
Bone regeneration strategies: engineered scaffolds, bioactive molecules and stem cells Current stage and future perspectives (2018, neutral): “By secreting inflammatory and chemotactic mediators such as Interleukin 6 (IL-6) and Chemokine ligand 2 (CCL2), the neutrophils recruit the second wave of inflammatory cells, the monocytes and macrophages [5, 7, 10].”
Inflammation, Fracture and Bone Repair (2016, background): “Typically this intramembranous bone formation begins in the inner layer of periosteum at some distance from the injury site, progressively advancing toward the fracture gap [18,43,52].”
The roles of vascular endothelial growth factor in bone repair and regeneration (2016, background): “In the first couple of days, neutrophils are recruited to the hematoma and phagocytose tissue debris and microorganisms [54].”