Absorption classification of oral drugs based on molecular surface properties.

By Christel A. S. Bergström, M. Strafford, L. Lazorova, A. Avdeef, K. Luthman, Per Artursson. 2003

238 citations recorded by the source corpus.

Subfields: Computational Theory and Mathematics, Pharmaceutical Science, Spectroscopy

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Computational Theory and Mathematics

1. John C. Dearden
2. Chi‐Yuan Wu
3. L. Benet

In Pharmaceutical Science

1. Chi‐Yuan Wu
2. L. Benet
3. John C. Dearden
4. M. Lindenberg
5. J. Dressman
6. S. Kopp

In Spectroscopy

1. L. Benet
2. John C. Dearden
3. Chi‐Yuan Wu

Citations in the corpus

• In silico prediction of aqueous solubility (2006, methodology): “Thus, hydrogen bonding may either increase or decrease solubility, depending on the three-dimensional molecular structure of the solute [31].”
• Predicting Drug Disposition via Application of BCS: Transport/Absorption/ Elimination Interplay and Development of a Biopharmaceutics Drug Disposition Classification System (2004, background): “Obviously, there will be gradations within each broad BCS class for the permeability and solubility parameters (16,40).”
• Classification of orally administered drugs on the World Health Organization Model list of Essential Medicines according to the biopharmaceutics classification system. (2004, background): “5 (sennosides) [12] Sodium iodide iodine deficiency High ??? 60 I/III [12] Spironolactone diuretic Low Low/High 25 II/IV* [12,16,35,272,273] Sulfadiazine antibacterial agent Low Low/High 500 II/IV [12,23,274,275] Sulfasalazine Colitis Ulcerosa/Morbus Crohn Low Low/High 500 II/IV [12,16,276,277] Tric”