Homocysteine Elicits a DNA Damage Response in Neurons That Promotes Apoptosis and Hypersensitivity to Excitotoxicity

By I. Kruman, C. Culmsee, Sic L. Chan, Y. Kruman, Zhihong Guo, Laroy Penix, Mark P. Mattson. Journal of Neuroscience, 2000

821 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Nutrition and Dietetics, Rheumatology

View Paper: https://www.semanticscholar.org/paper/b6724fbcf7b628868ecc601b32bf65d30e99ed0b

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In Nutrition and Dietetics

1. Youfa Wang

Citations in the corpus

• Folic Acid Deficiency and Homocysteine Impair DNA Repair in Hippocampal Neurons and Sensitize Them to Amyloid Toxicity in Experimental Models of Alzheimer's Disease (2002, background): “, 1997) or apoptosis triggered by DNA damage (Kruman et al., 2000).”
• Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. (2003, background): “Oxidative damage resulting from folate deprivation and homocysteine might be caused by increased cytosolic Ca2þ levels and DNA damage [6, 7 ].”
• Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis (2014, background): “Aside from its link to cardiovascular disease, Hcy was shown to have neurotoxic and excitotoxic properties in vitro [298,299], suggesting a direct influence on cognition.”