Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic.

By E. Prompetchara, C. Ketloy, T. Palaga. Asian Pacific Journal of Allergy and Immunology, 2020

1,440 citations recorded by the source corpus.

As the world is witnessing the epidemic of COVID-19, a disease caused by a novel coronavirus, SARS-CoV-2, emerging genetics and clinical evidences suggest a similar path to those of SARS and MERS. The rapid genomic sequencing and open access data, together with advanced vaccine technology, are expected to give us more knowledge on the pathogen itself, including the host immune response as well as the plan for therapeutic vaccines in the near future. This review aims to provide a comparative view among SARS-CoV, MERS-CoV and the newly epidemic SARS-CoV-2, in the hope to gain a better understanding of the host-pathogen interaction, host immune responses, and the pathogen immune evasion strategies. This predictive view may help in designing an immune intervention or preventive vaccine for COVID-19 in the near future.

Subfields: Infectious Diseases, Modeling and Simulation

View Paper: https://www.semanticscholar.org/paper/b638d404a28a56d5553e84bea7450712f5cf00ba

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In Infectious Diseases

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Citations in the corpus

• Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response (2020, positive): “The conditions are correlated with severity andmortality of this disease which suggest the potential of cytokines forming as found occurring in SARS-CoV and MERS-CoV infections [25].”