Tissue-level thresholds for axonal damage in an experimental model of central nervous system white matter injury.

By A. C. Bain, D. Meaney. Journal of Biomechanical Engineering, 2000

618 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Predictors for traumatic brain injuries evaluated through accident reconstructions. (2007, background): “The maximal principal strain has usually been chosen as a predictor of diffuse axonal injuries (Gennarelli et al., 1989; Thibault, 1990; Galbraith et al., 1993; Bain et al., 1996; Bain and Meaney, 2000; Morrison et al., 2003), as well as for mechanical injury to the blood-brain barrier (Shreiber et ”
Correlation of an FE Model of the Human Head with Local Brain Motion--Consequences for Injury Prediction. (2002, background): “However, Bradshaw and Morfey (2001) concluded that it is not acceptable to validate FE models for pressure and then use them for injury prediction.”
Fifty Shades of Brain: A Review on the Mechanical Testing and Modeling of Brain Tissue (2019, background): “Strikingly, for a swelling of only 10%, axonal strain, compression, and shear reach local maxima of up to 30%, and exceed the reported functional and morphological damage thresholds on the order of 20% [8].”