Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells

By R. Tibes, Y. Qiu, Yiling Lu, Bryan T. J. Hennessy, Michael Andreeff, Gordon B. Mills, S. Kornblau. Molecular Cancer Therapeutics, 2006

688 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b60d15dcc757bfa8ae2ade13037514a27ecba6bf

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Citations in the corpus

Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma. (2018, methodology): “Briefly, a fitted curve (‘‘supercurve’’) was plotted with the signal intensities on the Y-axis and the relative log2 concentration of each protein on the X-axis using the non-parametric, monotone increasing B-spline model (Tibes et al., 2006).”
Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas. (2017, neutral): “0.6 Saunders et al., 2012 RRID:SCR_005109; https://sites.google.com/site/ strelkasomaticvariantcaller/home SuperCurve Hu et al., 2007, Tibes et al., 2006 http://bioinformatics.mdanderson.org/main/ SuperCurve:Overview Survival N/A https://cran.r-project.org/package=survival TelSeq Ding et al., 2014…”
Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer. (2017, neutral): “A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript 2007; Hu et al., 2007; Liang et al., 2007; Tibes et al., 2006).”
The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge (2015, methodology): “The data archives are deposited to the TCGA DCC and include original images of protein arrays, calculated raw signals, relative concentrations of proteins, and normalised protein signals [24–28].”
An Integrative Genomic and Proteomic Analysis of PIK3CA, PTEN, and AKT Mutations in Breast Cancer (2008, methodology): “laboratory has been described previously (14, 15) and was used to quantify PTEN expression and phosphorylation of AKTat Thr(308) and Ser(473), glycogen”
Proteomics: Technologies and Their Applications. (2017, background): “The analysis of hematopoietic stem cell and primary leukemia samples through reverse-phase protein microarray was found to be highly reproducible and reliable for large-scale analysis of phosphorylation state and protein expression in human stem cells and acute myelogenous leukemia cells (70).”
The Library of Integrated Network-based Cellular Signatures (LINCS) NIH Program: System-level Cataloging of Human Cells Response to Perturbations (2017, methodology): “Regulatory relationships are inferred by extracting quantitative ME response phenotype features through multi-color imaging of biomarkers associated with specific cellular phenotypes, measurement of protein expression using RPPA (Tibes et al., 2006), and measurement of gene transcription using the L”
Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma (2017, positive): “5 mmol/L MgCl2, 1 mmol/L EGTA, 100 mmol/L NaF, 10 mmol/L NaPPi, 10% glycerol, 1 mmol/L phenylmethylsulfonyl fluoride, 1 mmol/L Na3VO4, and aprotinin 10 ug/mL) from human tumors and RPPA was performed as described previously (Gonzalez-Angulo et al., 2011; Hu et al., 2007; Tibes et al., 2006).”
Inferring causal molecular networks: empirical assessment through a community-based effort (2016, background): “RPPA is an antibody-based assay that provides quantitative measurements of protein abundance 28,44 .”