Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors

By J. Tobert. Nature reviews. Drug discovery, 2003

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Statin Safety and Associated Adverse Events: A Scientific Statement From the American Heart Association (2019, neutral): “Consequently, the initial prescribing information for lovastatin, simvastatin, and pravastatin required monitoring by slit-lamp examination for detection of lens opacities before starting treatment and periodically thereafter.(15,25)”
Optimization of Fermentation Parameters for Higher Lovastatin Production in Red Mold Rice through Co-culture of Monascus purpureus and Monascus ruber (2010, background): “This natural statin was the first fungal secondary metabolite to obtain approval from the US Food and Drug Administration in August 1987 (Tobert 2003; Demain 1999; Manzoni and Rollini 2002).”
Interpretation of the evidence for the efficacy and safety of statin therapy. (2016, background): “well as to determine whether it produces adverse effects on other causes of major morbidity and mortality.(174) For, although it may not always be possible to distinguish between adverse effects caused by lowering LDL cholesterol and those due to off-”