The Biological Activity of Human CD20 Monoclonal Antibodies Is Linked to Unique Epitopes on CD201
By J. Teeling, W. J. Mackus, L. Wiegman, Jeroen H. N. van den Brakel, S. Beers, R. French, Tom van Meerten, S. Ebeling, T. Vink, J. Slootstra and 3 more. Journal of Immunology, 2006
653 citations recorded by the source corpus.
Subfields: Hematology, Immunology, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/b59abc55031680b4859e211d1eb4194fb3190ad5
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In Radiology, Nuclear Medicine and Imaging
Citations in the corpus
- Antibody distance from the cell membrane regulates antibody effector mechanisms (2017, methodology): “The engagement of Ab effector mechanisms, such as CDC, can be influenced by the expression levels of the targeted Ag (21, 24, 25).”
- Statins Impair Antitumor Effects of Rituximab by Inducing Conformational Changes of CD20 (2008, background): “Most antiCD20 mAbs, including the rituximab, B1, and B9E9 studied in this work, recognize overlapping epitopes within the larger loop [33].”
- Engineered Protease-resistant Antibodies with Selectable Cell-killing Functions* (2013, background): “30846 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME 288 • NUMBER 43 • OCTOBER 25, 2013 ADCC was assessed with anti-CD20 variants using peripheral blood mononuclear effector cells allotyped to be heterozygous for the Fc RIIIa 158V/F polymorphism andWIL2-S target cells.”
- Daratumumab, a Novel Therapeutic Human CD38 Monoclonal Antibody, Induces Killing of Multiple Myeloma and Other Hematological Tumors (2011, methodology): “Lysis of Daudi cells and MM cells via CDC was measured by use of flow cytometry (FACSCalibur) after measurement of the percentage of propidium iodide (PI)-positive cells, as described previously (27, 28).”