Progression From Compensated Hypertrophy to Failure in the Pressure-Overloaded Human Heart: Structural Deterioration and Compensatory Mechanisms
By S. Hein, Eyal Arnon, S. Kostin, M. Schönburg, A. Elsässer, V. Polyakova, E. Bauer, W. Klövekorn, J. Schaper. Circulation, 2003
1,140 citations recorded by the source corpus.
Subfields: Cardiology and Cardiovascular Medicine, Epidemiology
View Paper: https://www.semanticscholar.org/paper/b57ec89a8598a095179942db9a874efa579ec941
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In Cardiology and Cardiovascular Medicine
- W. Paulus
- C. Tschöpe
- S. Rosenkranz
- Frank Flachskampf
- D. Brutsaert
- K. Weeks
- Bianca C. Bernardo
- J. McMullen
Citations in the corpus
- Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets (2015, background): “However, in a setting of heart disease, the rate of cardiomyocyte apoptosis can increase in the human heart (Hein et al. 2003; Narula et al. 1996; Olivetti et al. 1997) and based on animal studies contributes to decompensated hypertrophy and HF (Hayakawa et al.”
- Transforming Growth Factor (TGF)-β signaling in cardiac remodeling (2010, neutral): “Cardiac TGF-βwas also upregulated in patients with myocardial hypertrophy due to idiopathic hypertrophic cardiomyopathy [72], or aortic stenosis [73]; TGF-β levels correlated with the development of fibrosis [74].”
- TGF-β1 and angiotensin networking in cardiac remodeling (2004, background): “In the pressure-overloaded human heart, upregulation of ACE and TGF-h1 correlated with the degree of fibrosis [48].”
- Impact of Myocardial Fibrosis in Patients With Symptomatic Severe Aortic Stenosis (2009, neutral): “Posterior wall thickness (end diastolic), mm 14 (1) 13 (1) 13 (2) 0.”
- How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology. (2007, background): “In patients with aortic stenosis, who develop a depressed LVEF, this balance between proteolysis and antiproteolysis shifts(73) and important cardiomyocyte degeneration occurs.(74) Furthermore, in trabeculae of explanted human hearts, alterations of calcium handling have been observed which selectiv”