Dynamics and functions of lipid droplets
By James A. Olzmann, Pedro Carvalho. Nature reviews. Molecular cell biology, 2018
2,266 citations recorded by the source corpus.
Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They have a unique architecture consisting of a hydrophobic core of neutral lipids, which is enclosed by a phospholipid monolayer that is decorated by a specific set of proteins. Originating from the endoplasmic reticulum, lipid droplets can associate with most other cellular organelles through membrane contact sites. It is becoming apparent that these contacts between lipid droplets and other organelles are highly dynamic and coupled to the cycles of lipid droplet expansion and shrinkage. Importantly, lipid droplet biogenesis and degradation, as well as their interactions with other organelles, are tightly coupled to cellular metabolism and are critical to buffer the levels of toxic lipid species. Thus, lipid droplets facilitate the coordination and communication between different organelles and act as vital hubs of cellular metabolism. Lipid droplets are storage organelles that are important for the regulation of lipid and energy homeostasis, and that serve as buffers against lipotoxicity. Recent studies on the biology of lipid droplets have led to new discoveries about their biogenesis and the complexity of their interactions with other organelles at membrane contact sites.
Subfields: Biochemistry, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/b5754988c5a10cf94a661ea876a1feeb6175d393
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Biochemistry
In Molecular Biology
Citations in the corpus
- Reprogramming of fatty acid metabolism in cancer (2019, background): “2).(12,13) This is largely achieved through β-oxidation of stored lipids, leading to the production of acetyl-CoA through oxidative degradation of FAs.”
- The cell biology of ferroptosis (2024, neutral): “Lipid droplets consist of a neutral lipid core, composed mostly of TAG and steryl esters, encircled by a phospholipid monolayer containing integral and peripheral regulatory proteins 134 .”