A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery.

By Sung-Ching Chen, Yung-Chih Wu, F. Mi, Yu-Hsin Lin, L. Yu, Hsing‐Wen Sung. Journal of Controlled Release, 2004

887 citations recorded by the source corpus.

Subfields: Molecular Medicine, Pharmaceutical Science

View Paper: https://www.semanticscholar.org/paper/b5193f5dd1c4e2d4f37ea7af4b40f7421c655219

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Medicine

1. E. Chiellini
2. R. Ottenbrite
3. S. Hudson
4. Federica Chiellini
5. M. Dash

In Pharmaceutical Science

1. E. Chiellini
2. R. Ottenbrite
3. Federica Chiellini
4. M. Dash

Citations in the corpus

• Fundamental Concepts of Hydrogels: Synthesis, Properties, and Their Applications (2020, background): “In chitosan-based hydrogel formulations, formaldehyde is used as a crosslinking agent which releases the drug at a pH equal to the pH of stomach [52].”
• pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications (2017, background): “4, the blend swells extensively due to ionization of acid pendant group causing severe repulsion [95].”
• Chitosan—A versatile semi-synthetic polymer in biomedical applications (2011, background): “Genipin also provides extended drug release by chitosan hydrogels cross-linked in situ [179,190].”