Impact of storage conditions and storage time on silver nanoparticles' physicochemical properties and implications for their biological effects
By E. Izak-Nau, A. Huk, B. Reidy, H. Uggerud, M. Vadset, S. Eiden, M. Voetz, M. Himly, A. Duschl, M. Dusinska and 1 more. 2015
129 citations recorded by the source corpus.
It is increasingly recognized that nanoparticles (NPs) can ‘age’ while stored, and that the impact of this may lead to divergent results in terms of the observed toxicity of nominally the same NPs. The main goal of this study was to investigate whether (and to what extent) changes in silver (Ag) NPs' properties occur over time and whether storage of the dispersions under different conditions impacts their stability and ageing mechanism, as a function of the NPs' surface capping/charge. We found that both storage time/conditions and surface chemistry of AgNPs influenced the evolution of the NP properties over time, and that the resulting changes in the NPs' physicochemical properties influenced their toxicity. Observed changes in Ag NPs' toxicity were related to different processes such as NP agglomeration, dissolution, oxidation, capping agent degradation as well attachment of Ag+ ions to container walls. Thus, NP ‘aging’ effects as described here can be a significant contributor to the contradictory toxicity results observed in the literature for identical NPs, and NP ageing should thus be assessed in parallel with toxicity assessment as best practice.
Subfields: Biomaterials, Electronic, Optical and Magnetic Materials, Materials Chemistry
View Paper: https://www.semanticscholar.org/paper/b4d1df78d3f55dfbc4c628dbce9c5fedf6a06d80
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
- B. Drasler
- Phil Sayre
- A. Petri‐Fink
- K. Steinhäuser
- B. Rothen‐Rutishauser
- A. Grumezescu
- E. Andronescu
- A. Ficai
Citations in the corpus
- In vitro approaches to assess the hazard of nanomaterials (2017, methodology): “In some of the publications the cell proliferation rate, i.e. cell growth, was assessed (Armand et al., 2016a; Izak-Nau et al., 2015; Huk et al., 2015a) and the morphology has been observed by bright field microscopy (Huk et al., 2014).”
- Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview (2018, background): “The stability of AgNPs was previously investigated, where the reported data indicated that their stability actively influences their toxicity [60].”