Accumulation of different shapes of microplastics initiates intestinal injury and gut microbiota dysbiosis in the gut of zebrafish.
By Ruxia Qiao, Yongfeng Deng, Shenghu Zhang, M. Wolosker, Qiande Zhu, H. Ren, Yan Zhang. Chemosphere, 2019
737 citations recorded by the source corpus.
Different shapes of microplastics are widely detected in the environment and organisms and most of them remain in the gut. However, the influences of shapes on the bioaccumulation and toxicity of microplastics in the gut are largely unknown. Three shapes (bead, fragment, and fiber) of microplastics of comparable size in one dimension were prepared to exposure to zebrafish. The accumulation and toxicities of microplastics in the gut were detected. Shape-dependent accumulation in the gut was observed with the order of fibers (8.0 μg/mg) > fragments (1.7 μg/mg) > beads (0.5 μg/mg). The accumulation of microplastics caused multiple toxic effects in fish intestine, including mucosal damage, and increased permeability, inflammation and metabolism disruption. Based on these toxic effects, microplastic fibers resulted in more severe intestinal toxicity than microplastic fragments and beads did. Furthermore, microplastics also induced gut microbiota dysbiosis and specific bacteria alterations, which will provide novel insights into the potential mechanism of microplastics causing intestinal toxicities in fish. Our results also suggested that shape-depended effects should not be ignored in the health risk assessment of microplastics.
Subfields: Industrial and Manufacturing Engineering, Materials Chemistry, Pollution
View Paper: https://www.semanticscholar.org/paper/b4bcbc70f5fdb129c30d868e4a3a6b4df487fc2a
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In Industrial and Manufacturing Engineering
In Pollution
Citations in the corpus
- Microplastics in freshwater fishes: Occurrence, impacts and future perspectives (2021, background): “Changes in GIT morphology may also alter the types and activity of symbiotic microorganisms, resulting in gut dysbiosis and altered metabolism (Ding et al., 2020; Jabeen et al., 2018; Qiao et al., 2019; Xia et al., 2020; Zhao et al., 2020).”