The many roles for fluorine in medicinal chemistry.

By W. Hagmann. Journal of Medicinal Chemistry, 2008

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Fluorine in medicinal chemistry. (2015, background): “It seems likely, as has been suggested previously [7,123], that the continued interest in the development of improved synthetic methods for the introduction of fluorine [124–131]will lead in the future tomore effective utilization of the opportunities that fluorine substitution can bring.”
Visible light photocatalysis as a greener approach to photochemical synthesis. (2010, methodology): “The versatility of this method is attractive because the introduction of fluorinated substituents can substantially modulate both the bioactivity and pharmacokinetic properties of potential drug candidate”
Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis (2011, background): “The CF 3 group enjoys a privileged role in the realm of medicinal chemistry because its incorporation into small molecules often enhances efficacy by promoting electrostatic interactions with targets, improving cellular membrane permeability, and increasing robustness towards oxidative metabolism o”