Functions of zinc in signaling, proliferation and differentiation of mammalian cells

By D. Beyersmann, H. Haase. Biometals, 2001

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Zinc in wound healing: Theoretical, experimental, and clinical aspects (2007, background): “Apart from its importance in protein complexes, the zinc ion is closely involved in intracellular signaling and neurotransmission.(13,14) Zinc is second only to iron in being the most abundant trace element in the human body,(15) but its nutritional significance came to light only in the 1960s follo”
Zinc as a Gatekeeper of Immune Function (2017, background): “Besides cellular immune responses, zinc is also indispensable for proper RNA transcription, DNA synthesis, as well as cell survival [27,92].”
The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism. (2015, background): “When cells are cultured in high zinc conditions, cytosolic vesicles containing high amounts of zinc appear and are often referred to as zincosomes (31, 441).”
Mechanism of Zinc absorption in plants: uptake, transport, translocation and accumulation (2016, background): “In mammals, storage of cytosolic zinc in form of vesicles ‘zincosomes’ takes place to maintain metal homeostasis (Beyersmann and Haase 2001).”
Homeostasis and toxicology of essential metals (2012, background): “This would relate to the roles of Zn in metabolism and in particular to the fact that highly proliferating cells need more Zn (Beyersmann and Haase, 2001).”