Immuno-microbial pathogenesis of periodontitis: Keystones, pathobionts, and the host response
By G. Hajishengallis. Trends in immunology, 2013
1,017 citations recorded by the source corpus.
Recent studies have uncovered novel mechanisms underlying the breakdown of periodontal host-microbe homeostasis, which can precipitate dysbiosis and periodontitis in susceptible hosts. Dysbiotic microbial communities of keystone pathogens and pathobionts are thought to exhibit synergistic virulence whereby not only can they endure the host response but can also thrive by exploiting tissue-destructive inflammation, which fuels a self-feeding cycle of escalating dysbiosis and inflammatory bone loss, potentially leading to tooth loss and systemic complications. Here we discuss new paradigms in our understanding of periodontitis, which may shed light into other polymicrobial inflammatory disorders. In addition, we highlight gaps in knowledge required for an integrated picture of the interplay between microbes and innate and adaptive immune elements that initiate and propagate chronic periodontal inflammation.
Subfields: Periodontics, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/b44b8ad7e4e2c7ff90a3475207873b0899aba5be
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In Periodontics
Citations in the corpus
- The oral microbiome – an update for oral healthcare professionals (2016, background): “85,86 The dysbiotic microbiota induces the destruction of the periodontal tissue by a dysregulated host inflammatory immune response, which in turn provides new tissue breakdown-derived nutrients for the bacteria.”
- Mechanisms of Bone Resorption in Periodontitis (2015, background): “gingivalis could be a keystone pathogen of the diseaseprovoking periodontal microbiota [61–63].”