Repairing skeletal muscle: regenerative potential of skeletal muscle stem cells.

By Francesco Saverio Tedesco, A. Dellavalle, J. Díaz-Manera, G. Messina, G. Cossu. Journal of Clinical Investigation, 2010

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Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration (2011, background): “However, certain myogenic progenitor cells, such as the pericyte-derived mesoangioblasts, have the capacity to traverse tissues and they have been described as a potential source of stem cells capable of regenerating skeletal muscle (for a review, see Tedesco et al., 2010).”
Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis (2011, background): “Postnatally, the contribution of cell proliferation decreases, and hypertrophic growth and remodelling of pre-existing muscle fibres dominates; the resident stem cells (the satellite cells) are then mostly engaged in damage repai”
Effective fiber hypertrophy in satellite cell-depleted skeletal muscle (2011, result): “Another possible explanation for our findings is that some other progenitor cell population known to exist in adult muscle compensated for the loss of satellite cells (for a review, see Tedesco et al., 2010).”
Extracellular matrix: A dynamic microenvironment for stem cell niche (2014, background): “Once activated, a subset of satellite cells returns to the quiescent state in their original niche, thus providing the necessary replenishment for self-renewal [177].”