Mechanisms of cyclic-di-GMP signaling in bacteria.

By U. Jenal, J. Malone. Annual Review of Genetics, 2006

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Bacterial community assembly based on functional genes rather than species (2011, background): “Cyclic-di-GMP is an important secondary messenger, regulating the transition from amotile planktonic to a surface-associated biofilm lifestyle in a range of bacteria (34, 35), for example by up-regulating the production of adhesins and biofilmmatrix components (36–39) or downregulating motility gene”
Towards environmental systems biology of Shewanella (2008, background): “Bis-(3′-5′)-cyclic dimeric guanosine monophosphate (c-di-GMP) is emerging as an important intracellular signalling molecule that controls diverse functions, such as cellulose synthesis, biofilm formation, motility and bacterial virulence in gammaproteobacteri”
Automated Protein Structure Modeling with SWISS-MODEL Workspace and the Protein Model Portal (2012, background): “PleD catalyzes the condensation of two GTP molecules to the cyclic dinucleotide di-GMP (c-di-GMP), an ubiquitous second messenger in bacteria (79).”