Mapping the self in the brain's default mode network
By Christopher G. Davey, Jesús Pujol, Ben J. Harrison. NeuroImage, 2016
511 citations recorded by the source corpus.
The brain's default mode network (DMN) has become closely associated with self-referential mental activity, particularly in the resting-state. While the DMN is important for such processes, it has functions other than self-reference, and self-referential processes are supported by regions outside of the DMN. In our study of 88 participants, we examined self-referential and resting-state processes to clarify the extent to which DMN activity was common and distinct between the conditions. Within areas commonly activated by self-reference and rest we sought to identify those that showed additional functional specialization for self-referential processes: these being not only activated by self-reference and rest but also showing increased activity in self-reference versus rest. We examined the neural network properties of the identified 'core-self' DMN regions-in medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), and inferior parietal lobule-using dynamic causal modeling. The optimal model identified was one in which self-related processes were driven via PCC activity and moderated by the regulatory influences of MPFC. We thus confirm the significance of these regions for self-related processes and extend our understanding of their functionally specialized roles.
Subfields: Cognitive Neuroscience, Experimental and Cognitive Psychology
View Paper: https://www.semanticscholar.org/paper/b2e821d54e3fdd1e2e5f4f5b60c1f84e8310022a
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In Cognitive Neuroscience
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In Experimental and Cognitive Psychology
Citations in the corpus
- 20 years of the default mode network: a review and synthesis (2023, background): “The inherent constraints of current human imaging methodologies limit our ability to probe cellular mechanisms underlying the operations of the DMN. Translational studies in rodents offer possibilities for addressing critical gaps in our knowledge of network function and developing a deeper understa”
- REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics (2019, background): “…(Lebedev et al., 2015) and an acknowl-edgment of the looseness of this attributional exercise (mainly due to the intrinsic abstraction of the constructs in question, which is a challenge to surmount), we still largely maintain these views (see also Davey et al., 2016; Davey and Harrison, 2018).”