Regulation of endothelial permeability via paracellular and transcellular transport pathways.

By Y. Komarova, Asrar B. Malik. Annual Review of Physiology, 2010

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The delivery of therapeutic oligonucleotides (2016, background): “In most tissues the capillary lumen is surrounded by a layer of endothelial cells that tightly abut upon each other and are joined together by VE-cadherin containing adherence junctions and by occludin and claudin-containg tight junctions, thus forming a barrier between blood and the parenchymal spa”
VE-cadherin and endothelial adherens junctions: active guardians of vascular integrity. (2013, neutral): “, 2009), rearrangement of the cytoskeleton (Komarova and Malik, 2010), tight junction remodeling, and gene transcription (Taddei et al.”
CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future (2020, background): “Furthermore, the cargo must reach the target tissue and bypass the vascular endothelium, which are often tightly connected by cell-cell junctions (101), preventing accessibility to larger delivery vehicles (>1 nm diameter).”