Descending control of nociception: Specificity, recruitment and plasticity.

By M. Heinricher, Isaura Tavares, J. Leith, B. Lumb. Brain Research Reviews, 2009

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Central mechanisms of pathological pain (2010, background): “Pharmacological manipulations that increase synaptic levels of serotonin and noradrenaline, such as the use of tricyclic antidepressants and other classes of antidepressant, have gained prominence in the clinical management of chronic pain, particularly in therapy-resistant states such as neuropathi”
Descending pain modulation and chronification of pain (2014, positive): “The existence of oncells and off-cells with descending projections to the spinal dorsal horns provides a neuronal context for positive and negative pain modulation from the PAG/RVM system [60].”
The central sensitization inventory: A user’s manual (2018, background): “…have been identified, including dysregulation of ascending and descending tracks in the central nervous system (Ren & Dubner, 2002; Yunus, 2007; Heinricher et al., 2009; van Wijk & Veldhuijzen, 2010; Kindler, Bennett, & Jones, 2011); over- activation of glial cells, resulting in the release of…”
Nociceptors: the sensors of the pain pathway. (2010, background): “itization of pain perception relative to other competing behavioral needs and homeostatic demands (39).”