Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review.

By N. Molodecky, I. Soon, D. Rabi, W. Ghali, Mollie Ferris, G. Chernoff, E. Benchimol, R. Panaccione, Subrata Ghosh, H. Barkema and 1 more. Gastroenterology, 2012

4,817 citations recorded by the source corpus.

Subfields: Genetics, Public Health, Environmental and Occupational Health, Rheumatology

View Paper: https://www.semanticscholar.org/paper/b2aa2d9bcba0b056a6617648d475b214899b297f

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In Genetics

1. Judy H. Cho
2. G. Kaplan
3. Andre Franke
4. Mark J. Daly
5. B. B. Finlay
6. Matthew Stephens
7. T. Kanai
8. K. Matsuoka

In Public Health, Environmental and Occupational Health

1. Judy H. Cho
2. G. Kaplan

In Rheumatology

1. Mark J. Daly

Citations in the corpus

• Fine-mapping inflammatory bowel disease loci to single variant resolution (2017, methodology): “We removed variants with missing data rate >2% across the whole dataset, or > 10% in any one batch, and variants that failed (false discovery rate (FDR) < 10 -5 in either the whole dataset or at least two batches) tests for the following: (1) Hardy-Weinberg equilibrium in controls; (2) differential ”
• Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations (2019, background): “diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet. 8, e1002607 (2012). 18. Teslovich, T.M. et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466, 707–713 (2010). 19. Lee, S.H. et al. Estimation of pleiotropy between c”
• The Intestinal Microbiome in Early Life: Health and Disease (2014, background): “Europe and North America have the highest levels of both CD and UC incidence, with over 300 per 100,000 cases for CD and 90–505 per 100,000 cases for UC (168) and 20–30% of diagnoses are made in the pediatric population (169).”
• Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations (2015, neutral): “diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet. 8, e1002607 (2012). 18. Teslovich, T.M. et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466, 707–713 (2010). 19. Lee, S.H. et al. Estimation of pleiotropy between c”
• Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn’s disease, produces an inflammatory polysaccharide (2019, background): “Incidence of CD is increasing worldwide (8), and has been linked to adoption of a Western diet (9).”
• Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. (2017, background): “…studies (103 of Crohn’s disease and 101 of ulcerative colitis) 69 prevalence studies (61 of Crohn’s disease and 60 of ulcerative colitis) 95 studies derived from Molodecky et al (2012)⁵ 52 new studies found in the review Figure 2: Worldwide incidence of Crohn’s disease and ulcerative colitis.”
• Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies (2017, background): “Thus, IBD is becoming a major global public health problem [5, 6].”