Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map

By Sean R. Collins, K. Miller, Nancy L. Maas, Assen Roguev, Jeffrey Fillingham, Clement S. Chu, Maya Schuldiner, Marinella Gebbia, J. Recht, M. Shales and 18 more. Nature, 2007

934 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b1e1a57c923626a625a66a8fe39621f870aa5439

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In Molecular Biology

1. Roded Sharan
2. Trey Ideker
3. J. H. Morris
4. Nevan J. Krogan
5. Xiang-Jiao Yang
6. Gary D. Bader
7. E. Seto
8. E. Jeng

Citations in the corpus

• Protein networks in disease. (2008, methodology): “Reproduced from Chuang et al. (2007) with permission from Macmillan Publishers Ltd.”
• Differential network biology (2012, background): “…in contrast, chart pairs of genetic mutations that in combination cause lethality or other phenotype—information that complements the structural information provided by the physical network (Tong et al , 2001; Roguev et al , 2007; Butland et al , 2008; Typas et al , 2008; Horn et al , 2011).”
• HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention (2007, background): “Different laboratories have recently reported that yeast Rtt109 (regulation of retrotransposition 109) efficiently acetylates lysine 56 of yeast histone H3 (Ivanov et al., 2002; Collins et al., 2007; Driscoll et al., 2007; Han et al., 2007; Tsubota et al., 2007; Xhemalce et al., 2007).”
• clusterMaker: a multi-algorithm clustering plugin for Cytoscape (2011, methodology): “Two yeast epistatic miniarray profiles (EMAPs) were also used: chromosome biology [53] and RNA processing [54] to provide genetic interaction data as a complement to the protein-protein interaction data set.”
• Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions (2017, positive): “We chose a set of 79 non-essential genes that modulated the cellular susceptibility to ricin (Supplementary Table 5,6) in a genome-wide CRISPR-Cas9 ricin screen 29 (Supplementary Fig.”
• Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction (2009, positive): “For example, most mutations exhibit enhanced growth defects when paired with certain other mutations, and one study in yeast identified an average of six genetic interactions per gene (Collins et al., 2007).”