Dopamine Dependency of Oscillations between Subthalamic Nucleus and Pallidum in Parkinson's Disease

By Peter Brown, A. Oliviero, P. Mazzone, A. Insola, P. Tonali, V. Di Lazzaro. Journal of Neuroscience, 2001

1,157 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/b1c7bbb446b74e0ff7099b52ed9fc6825bdf31a7

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Citations in the corpus

Pathophysiology of bradykinesia in Parkinson's disease. (2001, background): “In a recent report, Brown carried this idea one stage further by examining the effect of dopaminergic stimulation on the coupling of activity between different nuclei of the basal ganglia (Brown et al., 2001).”
Activity Patterns in a Model for the Subthalamopallidal Network of the Basal Ganglia (2002, background): “…dopamine depletion, and in patients with Parkinson’s disease, strongly correlated rhythmic activity can be observed in both the subthalamic nucleus and in the globus pallidus external segment (Bergman et al., 1994; Nini et al., 1995; Magnin et al., 2000; Raz et al., 2000; Brown et al., 2001).”
The role of oscillations and synchrony in cortical networks and their putative relevance for the pathophysiology of schizophrenia. (2008, background): “In Parkinson disease, reduced dopaminergic control leads to the instability to desynchronize these beta oscillations that prevail in the rest condition and need to be replaced by gamma oscillations in order to enable the initiation of voluntary movements.(65)”
Abnormal neural oscillations and synchrony in schizophrenia (2010, background): “Interestingly, there is evidence suggesting that dopamine agonists decrease pathological beta-band oscillations and increase gamma-band oscillations in cortical and subcortical network”
Oscillations in the Basal Ganglia: The good, the bad, and the unexpected (2005, background): “, 2005a), and PD patients before and after treatment with levodopa (Brown et al., 2001; Silberstein et al., 2003; Priori et al., 2004).”
Functional organization of the basal ganglia: Therapeutic implications for Parkinson's disease (2008, background): “(b) In the ‘‘On’’ pharmacological state there is a predominant 60–80 Hz g band peak while the beta rhythm is drastically attenuated.(48) (c) In patients with LID there is predominant 4–10 Hz activity.”
Oscillations and the basal ganglia: Motor control and beyond (2013, neutral): “, 2007) and is instead replaced by increased synchronisation in the theta and gamma bands (Alonso-Frech, 2006; Brown et al., 2001).”
Efficiency and Cost of Economical Brain Functional Networks (2007, background): “oscillations in the basal ganglia and cortex [29–33].”
Translational principles of deep brain stimulation (2007, background): “This specific oscillatory activity decreased when patients started taking medication, but led instead to spontaneous synchronization at frequencies in the gamma ban”
Normal and pathological oscillatory communication in the brain (2005, background): “In patients with Parkinson's disease who have been treated with dopaminergic drugs, coherence of LFPs between the STN and GPi occurs at ∼60–80 Hz, which resembles the normal stat”
Reduction in subthalamic 8–35 Hz oscillatory activity correlates with clinical improvement in Parkinson's disease (2006, background): “Gamma peaks were defined ON-med because gamma activity is more likely to occur during dopaminergic stimulation (Brown et al., 2001; Cassidy et al., 2002).”
High Frequency Stimulation of the Subthalamic Nucleus Eliminates Pathological Thalamic Rhythmicity in a Computational Model (2004, background): “In particular, numerous experimental studies have demonstrated that neurons within both the STN and GPi show an increased level of synchrony and bursting activity during parkinsonian states (Bergman et al., 1994; Nini et al., 1995; Magnin et al., 2000; Raz et al., 2000; Brown et al., 2001).”
Beta-band oscillations--signalling the status quo? (2010, neutral): “Interestingly, treatment with the dopamine precursor levodopa reduced BBA and resulted in a new coherence peak at 70 Hz in the gamma-band [68] (Figure 2a).”
High-Frequency Stimulation of the Subthalamic Nucleus Suppresses Oscillatory β Activity in Patients with Parkinson's Disease in Parallel with Improvement in Motor Performance (2008, neutral): “Our findings give correlative evidence that HFS may act by reducing oscillatory STN LFP activity in PD patients, thereby mirroring the effect of levodopa on this activity (Brown et al., 2001; Priori et al., 2004; Kühn et al., 2006).”
Event-related beta desynchronization in human subthalamic nucleus correlates with motor performance. (2004, background): “The choice of this band was further justi®ed as activity in this range displays signi®cant coherence with widespread cortical areas and the globus pallidus internus (Brown et al., 2001; Williams et al., 2002) and with single-unit activity in STN (Levy et al., 2002a).”