A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

By N. Bouatia-Naji, A. Bonnefond, Christine Cavalcanti-Proença, T. Sparsø, J. Holmkvist, Marion Marchand, J. Delplanque, S. Lobbens, G. Rocheleau, E. Durand and 31 more. Nature Genetics, 2009

618 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Endocrinology, Diabetes and Metabolism, Genetics

View Paper: https://www.semanticscholar.org/paper/b1b6d3fcf9555183daca967c814aba1fb3c1632c

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In Endocrine and Autonomic Systems

In Endocrinology, Diabetes and Metabolism

In Genetics

Citations in the corpus

Human genetic variation and its contribution to complex traits (2009, background): “For example, the genetic propensity to develop type 2 diabetes (T2D) seems to involve genes in several different pathways that affect pancreatic β-cell formation and function, as well as pathways affecting fasting glucose levels and obesit”
Uncovering the roles of rare variants in common disease through whole-genome sequencing (2010, methodology): “This assumption has controlled much of the follow-up research, in which the focus has generally been on resequencing in the linkage disequilibrium block defined by common variant”
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis (2010, background): “Fourteen signals reaching genome-wide significance Two of the 14 signals reaching genome-wide significance on joint analysis (those near MTNR1B and IRS1 ) represent loci for which T2D associations have been recently reported in samples which partially overlap with those studied her”
Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus (2016, background): “A possible link between circadian clocks, regulation of glucose metabolism, and melatonin signaling in the pancreas was indicated by genetic studies (255).”
Melatonin--a pleiotropic, orchestrating regulator molecule. (2011, background): “The human MT2 polymorphisms associated with increased risk for developing diabetes type 2 (Staiger et al., 2008; Bouatia-Naji et al., 2009; Lyssenko et al., 2009; Shieh et al., 2009; Sparsø et al., 2009; Liu et al., 2010) may be interpreted in this context.”
International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors (2010, background): “sons with genetic variations in the MTNR1B gene encoding the MT2 melatonin receptor (Bouatia-Naji et al., 2009; Lyssenko et al., 2009; Prokopenko et al., 2009).”
The mammalian circadian timing system: organization and coordination of central and peripheral clocks. (2010, background): “Genetic studies in humans have revealed a possible link between MTNR1B allele variants and hyperglycemia, impaired earlyphase insulin secretion, and β-cell function (258, 259).”