The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications.

By N. Mitsiades, C. Mitsiades, P. Richardson, V. Poulaki, Y. Tai, D. Chauhan, G. Fanourakis, Xuesong Gu, Charles Bailey, Marie G. Joseph and 5 more. Blood, 2003

747 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/b14df5fb59dcd99cbe4972f8fa68033b17f6850b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. J. Adams
2. Véronique Baud
3. P. Richardson
4. T. Hideshima
5. M. Karin
6. L. Gianni
7. S. Rajkumar
8. N. Perkins

In Oncology

1. J. Adams
2. Véronique Baud
3. M. Karin
4. L. Gianni
5. N. Perkins
6. Bharat B. Aggarwal
7. S. Rajkumar
8. S. Grivennikov

Citations in the corpus

• Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity (2004, background): “proteasome inhibitor PS-341 sensitized multiple myeloma cell lines and patient cells to DOX, including cells resistant to either drug or cells isolated from a patient who had relapsed after proteasome inhibitor monotherapy (Mitsiades et al., 2003).”
• Is NF-κB a good target for cancer therapy? Hopes and pitfalls (2009, background): “Although bortezomib affects other signalling pathways, its efficacy may in part be due to inhibition of NF-κB activit”
• Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets (2007, background): “For example, gene and protein profiling of bortezomib-treated multiple myeloma cells shows cleavage of DNA repair enzyme”
• The proteasome: a suitable antineoplastic target (2004, positive): “Others have shown that low-dose bortezomib sensitizes chemotherapy-resistant multiple-myeloma cells and cells obtained from a patient with relapsed disease to chemotherapy with doxorubicin and melphala”