Structure-based thresholds of toxicological concern--guidance for application to substances present at low levels in the diet.

By R. Kroes, A. Renwick, M. Cheeseman, J. Kleiner, I. Mangelsdorf, A. Piersma, B. Schilter, J. Schlatter, F. V. Schothorst, J. Vos and 1 more. 2005

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Correlation of chemical structure with reproductive and developmental toxicity as it relates to the use of the threshold of toxicological concern. (2012, methodology): “Chemical inclusion criteria In developing chemical inclusion criteria, we applied guidance for application of the TTC concept published by the ILSI-EU Expert Group (Kroes et al., 2004).”
Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European Chemicals Legislation (REACH) (2008, methodology): “…human exposure and the application of negligible or no human exposure, e. g. according to the concept of Toxicological Thresholds of Concern (TTC, Kroes et al. 2004; ECB 2007) and (2) the use of non-testing methods for gaining data on toxicological endpoints such as grouping or the chemical…”