Arsenic exposure from drinking water, and all-cause and chronic-disease mortalities in Bangladesh (HEALS): a prospective cohort study
By Maria Argos, Tara Kalra, Paul J. Rathouz, Yu Chen, Brandon L. Pierce, F. Parvez, Tariqul Islam, Alauddin Ahmed, M. Rakibuz‐Zaman, Rabiul Hasan and 5 more. The Lancet, 2010
669 citations recorded by the source corpus.
Summary Background Millions of people worldwide are chronically exposed to arsenic through drinking water, including 35–77 million people in Bangladesh. The association between arsenic exposure and mortality rate has not been prospectively investigated by use of individual-level data. We therefore prospectively assessed whether chronic and recent changes in arsenic exposure are associated with all-cause and chronic-disease mortalities in a Bangladeshi population. Methods In the prospective cohort Health Effects of Arsenic Longitudinal Study (HEALS), trained physicians unaware of arsenic exposure interviewed in person and clinically assessed 11 746 population-based participants (aged 18–75 years) from Araihazar, Bangladesh. Participants were recruited from October, 2000, to May, 2002, and followed-up biennially. Data for mortality rates were available throughout February, 2009. We used Cox proportional hazards model to estimate hazard ratios (HRs) of mortality, with adjustment for potential confounders, at different doses of arsenic exposure. Findings 407 deaths were ascertained between October, 2000, and February, 2009. Multivariate adjusted HRs for all-cause mortality in a comparison of arsenic at concentrations of 10·1–50·0 μg/L, 50·1–150·0 μg/L, and 150·1–864·0 μg/L with at least 10·0 μg/L in well water were 1·34 (95% CI 0·99–1·82), 1·09 (0·81–1·47), and 1·68 (1·26–2·23), respectively. Results were similar with daily arsenic dose and total arsenic concentration in urine. Recent change in exposure, measurement of total arsenic concentrations in urine repeated biennially, did not have much effect on the mortality rate. Interpretation Chronic arsenic exposure through drinking water was associated with an increase in the mortality rate. Follow-up data from this cohort will be used to assess the long-term effects of arsenic exposure and how they might be affected by changes in exposure. However, solutions and resources are urgently needed to mitigate the resulting health effects of arsenic exposure. Funding US National Institutes of Health.
Subfields: Environmental Chemistry, Health, Toxicology and Mutagenesis, Pollution
View Paper: https://www.semanticscholar.org/paper/b1353f72d9ec27ee5816e8fbb61c13c7bd93933d
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Environmental Chemistry
In Health, Toxicology and Mutagenesis
In Pollution
Citations in the corpus
- Arsenic exposure and toxicology: a historical perspective. (2011, background): “…relationship between prevalence rates of QT prolongation and water As concentrations; measuring QT interval may detect early cardiac As cardiac toxicity Argos et al. (2010) Bangladesh, >10,000 in survey 0.01–864 ppb Chronic As exposure via drinking water associated with increased…”
- The effects of heavy metals on human metabolism (2019, background): “Therefore, arsenic pollution is of global concern (Rahman 2002; Argos et al. 2010).”
- Arsenic contamination, consequences and remediation techniques: a review. (2015, background): “gions, Sonora (Mexico), Pamplonian Plain (Argentina), West Bengal (India), Northern Chile, and Bangladesh (Argos et al., 2010).”
- The roles of membrane transporters in arsenic uptake, translocation and detoxification in plants (2020, background): “2020 Taylor & Francis Group, LLC exposure to As can cause various human diseases such as cardiovascular diseases, neurological disorders and skin cancer (Argos et al., 2010; Chen, Graziano et al., 2011; IARC, 2004; Li et al., 2017).”