Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression.

By G. Borsellino, Markus Kleinewietfeld, Diletta Di Mitri, Alexander Sternjak, A. Diamantini, Raffaella Giometto, S. Höpner, D. Centonze, G. Bernardi, M. Dell’Acqua and 4 more. Blood, 2007

1,286 citations recorded by the source corpus.

Subfields: Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/b0e70e1e2c8843a268d3d8250a85ecb61f0718a9

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In Immunology

1. Laura M. McLane
2. Mohamed S. Abdel-Hakeem
3. Angelika Schmidt
4. P. Krammer
5. E. Wherry
6. Nina Oberle
7. Rafi Ahmed
8. A. Schietinger

In Physiology

1. P. Pacher
2. Luca Antonioli
3. E. Vizi
4. Angelika Schmidt
5. P. Krammer
6. G. Haskó
7. G. Burnstock
8. Nina Oberle

Citations in the corpus

• CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer. (2019, background): “Adenosine can also act as an immunoregulatory signal in some settings where extracellular ATP/ADP is hydrolyzed to release adenosine that can signal through A2AR and other adenosine receptors to suppress T cell function and contribute to exhaustion (192, 193).”
• Molecular Mechanisms of Treg-Mediated T Cell Suppression (2012, background): “Nevertheless, mice with T cell-specific TGF-β1 deficiency showed enhanced Th1 and Th2 responses and immunopathology including colitis, underscoring the importance of T cell-produced TGF-β; however, these mice were resistant to the induction of experimental autoimmune encephalitis (EAE) likely due to”
• Purinergic signalling and disorders of the central nervous system (2008, background): “Patients with the remitting/relapsing form of MS have strikingly reduced numbers of NTPDase1-positive Treg cells, suggesting that purines might be involve”
• CD39 and CD73 in immunity and inflammation (2013, positive): “Indeed, murine Tregs display increased CD39 activity only upon activation of their Tcell receptor (TCR), and this enzyme was found to be inactive in non-stimulated cells [43] (Figure 2).”
• Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia (2020, background): “They express the forkhead box transcription factor Foxp3, but can also be identi fi ed by detecting the high expression of the IL ‐ 2 receptor α ‐ chain (CD25) and low/null expression of IL ‐ 7 receptor α ‐ chain (CD127) 29 , along with other surface molecules such as CD39 and CD73 30,31 .”