Smad regulation in TGF-beta signal transduction.
By A. Moustakas, S. Souchelnytskyi, C. Heldin. Journal of Cell Science, 2001
938 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/b0e5018cc3681d40ddb84a4fe7958403c2a316c0
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Citations in the corpus
- Smad3 as a mediator of the fibrotic response (2004, background): “The eight mammalian Smads are grouped into three subfamilies, the five receptor-activated Smads (R-Smads), the one common mediator Smad (Co-Smad) and the two inhibitory Smads (I-Smads) (Moustakas et al. 2001; Derynck & Zhang 2003; Shi &Massague 2003).”
- Targeting cancer stem cell pathways for cancer therapy (2020, background): “Based on Smad structure and functions, Smad proteins can be divided into three subfamilies: receptor-activated or pathway-restricted Smad (RSmads), Co-Smad, and inhibitory Smad (I-Smads), which includes at least nine Smad proteins.(341,342) R-Smads are activated by type I receptors and form transien”
- Non-Smad TGF-β signals (2005, background): “…can be classified into two branches: (1) the TGF-β branch, represented by ligands such as TGF-β, activin, nodal or myostatin, which activate Smad2 and Smad3; and (2) the BMP branch, represented by ligands such as BMPs and GDFs, which activate Smad1, Smad5 and Smad8 (Moustakas et al., 2001).”
- Cardiac fibroblasts: at the heart of myocardial remodeling. (2009, background): “The classical signaling cascade from stimulation of the TGF-β receptor involves Smad proteins which are phosphorylated and translocate to the nucleus where they act as transcription factors (Moustakas et al., 2001).”
- TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis (2016, background): “As SMAD3 binds to DNA directly, whereas SMAD2 does not, these two SMADs may have distinct effects on the regulation of target genes.”