Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples.

By Xianlin Han, R. Gross. Mass spectrometry reviews (Print), 2005

1,083 citations recorded by the source corpus.

Subfields: Molecular Biology, Spectroscopy

View Paper: https://www.semanticscholar.org/paper/b0c9dcf5d059a3af13e8cc60bd8c7bf83ad13ffb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. David S. Wishart
2. Jianguo Xia
3. Igor Sinelnikov
4. R. Mandal
5. Anchi Guo
6. Craig Knox
7. J. Sampaio
8. Weiqi Li

In Spectroscopy

1. Jianguo Xia
2. David S. Wishart
3. Igor Sinelnikov
4. R. Mandal
5. J. Sampaio
6. Weiqi Li
7. Andrej Shevchenko
8. Ruth Welti

Citations in the corpus

• Lipids in exosomes: Current knowledge and the way forward. (2017, background): “It should however be mentioned that it has for many years been well-known that different lipid species may contribute to differentMS signal intensities [26,27].”
• The Human Serum Metabolome (2011, methodology): “One approach, known as ‘‘shotgun’’ lipdiomics [88,89], uses LC-MS techniques to separate lipid classes and mass fragment libraries to identify lipid types.”
• Innovation: Metabolomics: the apogee of the omics trilogy (2012, background): “Given the challenge of predicting tandem mass spectrometry (MS/MS) fragmentation patterns for most metabolites, untargeted metabolomic profiling data are typically acquired in MS 1 mode (that is, only the mass-to-charge ratio ( m/z ) of the intact metabolite is measured”
• A novel informatics concept for high-throughput shotgun lipidomics based on the molecular fragmentation query language (2011, background): “The isotopic correction algorithm adjusts the intensities of peaks within partially overlapping isotopic clusters of neighboring lipid species [7,12,20].”
• LipidXplorer: A Software for Consensual Cross-Platform Lipidomics (2012, background): “However, currently the largest body of shotgun lipidomics work is performed using triple quadrupole or triple quadrupole - linear ion trap (QTRAP) mass spectrometers (reviewed in [1,4,14,28,29]) by precursor- or neutral loss scanning [9,30].”
• Profiling lipid changes in plant response to low temperatures (2006, methodology): “Approaches based on electrospray ionization tandem mass spectrometry (ESI-MS/MS) have been developed to comprehensively analyze lipid composition in animals, yeast, and plants (Brügger et al. 1997, Welti et al. 2002, Welti and Wang 2004, Han and Gross 2005, Wenk 2005).”