Hippocampal synaptic plasticity, spatial memory and anxiety

By D. Bannerman, R. Sprengel, D. Sanderson, S. McHugh, J. Rawlins, H. Monyer, P. Seeburg. Nature Reviews Neuroscience, 2014

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Recent studies using transgenic mice lacking NMDA receptors in the hippocampus challenge the long-standing hypothesis that hippocampal long-term potentiation-like mechanisms underlie the encoding and storage of associative long-term spatial memories. However, it may not be the synaptic plasticity-dependent memory hypothesis that is wrong; instead, it may be the role of the hippocampus that needs to be re-examined. We present an account of hippocampal function that explains its role in both memory and anxiety.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/b0b47c28536f3f65d47e2aaf99216b4f61b01ca8